Evaluation of the in-vitro antifungal activity of Holoptelea Integrifolia ethanolic extract loaded in microemulsion

Microemulsions improve the transdermal delivery of several drugs over conventional topical preparations such as emulsions and gels: enhanced drug solubilization, increased skin flux, decreased diffusion coefficient. Microemulsion-based systems find significant improvement in antifungals. We believe that drug-loaded microemulsion will show better antifungal activity by penetration into fungal cells. Antifungal agents are mostly lipophilic easily formulated vehicles. were prepared phase titration method. Formulations same Excipient ratio different concentrations optimized with selected parameters like pseudo ternary diagram, particle analysis size, zeta potential validation, entrapment efficiency, release studies performed dialysis bag techniques at a temperature (37ºC). The study continued for 24 hours. maximum amount Holoptelea integrifolia is 90% within 8hr. was monitored 37ºC. Successfully done preparation, characterization, Microemulsion loaded.